Endocrine Abstracts

Objectives: The mortality in thyroid cancer (TC) is unacceptably high and novel immune based strategies are necessary, especially for cancers that are resistant to existing therapies. Recently, the receptor SIGLEC15 has been proposed as potential novel target in different cancers, but little is known about its exact function and regulation. Given its high expression in tumor associated macrophages and the high density of these cell in thyroid cancer makes this anti-inflammator...

Objectives: Anaplastic thyroid carcinoma (ATC) is one of the malignancies with the highest mortality among all cancers. Immune cells are highly abundant in ATC tumors and increased infiltration with tumor-associated macrophages is associated with decreased survival. We hypothesize that systemic inflammatory markers are also associated with survival in patients with ATC and are more elevated in ATC compared to poorly differentiated thyroid carcinoma (PDTC).<p class="abstext...

Background: Accumulating evidence indicates the presence of bidirectional cross-talks between the endocrine and the immune system. However, no data are available on the influence of either the thyroid hormones or TSH within the normal range on the immune cell function in healthy humans.Aim: To comprehensively investigate the effects of the hypothalamic-pituitary-thyroid axis on the variation of immune responses in a cohort of healthy volunteers.<p cl...